Viral Etiology for Parkinson's Disease

Discussion: Viral Etiology

Disease etiology and diagnosis by TCR repertoire analysis goes viral.

The importance of T-cell receptor (TCR) repertoire diversity is highlighted in murine models of immunodeficiency and in many human pathologies. However, the true extent of TCR diversity and how this diversity varies in health and disease is poorly understood. In a previous issue of the European Journal of Immunology, Lossius et al. [Eur. J. Immunol. 2014. 44: 3439-3452] dissected the compositio...

Viral perturbations of host networks reflect disease etiology

Viral Perturbations of Host Networks Reflect Disease Etiology

Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viru...

Etiology of Chinaberry Gall Disease in Iran

Chinaberry (Melia azedarach L.) is a beautiful tree indigenous to the Himalayas that grows as a native plant in Iran. Symptoms similar to bacterial gall have been observed on the crown, shoot and twig of chinaberry, a recent landscape tree since 2003-2004 in Shiraz, Fars province, south of Iran. A gram negative bacterium was isolated from the galls. The isolates did not produce fluorescent pigm...